Inflammatory bowel disease attacks quickly and makes patients miserable. Recently, British researchers found the key factors causing inflammatory bowel disease. Now let's take a look at the key factors caused by inflammatory bowel disease!
최근에 영국 연구팀은 T{0}}라는 단백질이 장 면역 체계와 장내 세균총 사이의 섬세한 균형을 유지하는 데 중요한 역할을 한다는 것을 발견했습니다. 실험에 따르면 이 단백질이 제거되면 마우스에서 인간 염증성 장 질환(IBD)과 유사한 증상이 나타날 수 있습니다. 따라서 연구자들은 단백질이 장 면역계에 미치는 영향이 연구 방향으로 사용될 수 있고 마침내 염증성 장 질환의 치료를 위한 새로운 방법 개발의 길을 열 수 있다고 믿고 있습니다. 관련 연구 결과는 면역학 저널(Journal of Immunology) 최신호 온라인판에 게재됐다.
Inflammatory bowel disease refers to ulcerative colitis and Crohn's disease. This disease is common in western countries, and the prevalence rate in China has also begun to rise sharply in recent years. The etiology of inflammatory bowel disease is still unclear, but most studies have targeted the intestinal immune system. A large number of bacteria are parasitic in the human intestine, which plays an important role in maintaining human health. Under normal circumstances, the intestinal immune system will not respond to the activities of beneficial bacteria in the intestine, but only play a role when the internal balance is destroyed. The intestinal immune system of patients with inflammatory bowel disease is different. It will make an immune response to the beneficial flora in the intestine, leading to chronic inflammation.
In a research project funded by the British Medical Research Council and the Wellcome foundation, the research team led by Professor Graham Lord of King's College London found that a protein called T-bet has a strong influence on the interaction between cells of the intestinal immune system. The deletion of this protein will lead to the dysfunction of immune cells, cause inflammation and eventually lead to the occurrence of inflammatory bowel disease. Experiments have proved that once the T-bet protein in the mouse immune system is removed, it will lead to the symptoms similar to human inflammatory bowel disease in mice; Using these proteins as therapeutic targets can reverse the symptoms of inflammatory bowel disease in mice.
연구자들은 이번 연구가 염증성 장질환을 유발할 수 있는 면역 세포와 분자 과정을 처음으로 확인하는 데 큰 의미가 있다고 지적했다. T{0}단백질 강화
